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 <front>
  <journal-meta>
   <journal-id journal-id-type="publisher-id">Herald of Technological University</journal-id>
   <journal-title-group>
    <journal-title xml:lang="en">Herald of Technological University</journal-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ВЕСТНИК ТЕХНОЛОГИЧЕСКОГО УНИВЕРСИТЕТА</trans-title>
    </trans-title-group>
   </journal-title-group>
   <issn publication-format="print">3034-4689</issn>
  </journal-meta>
  <article-meta>
   <article-id pub-id-type="publisher-id">60857</article-id>
   <article-categories>
    <subj-group subj-group-type="toc-heading" xml:lang="ru">
     <subject>БИОХИМИЯ И БИОТЕХНОЛОГИЯ</subject>
    </subj-group>
    <subj-group subj-group-type="toc-heading" xml:lang="en">
     <subject></subject>
    </subj-group>
    <subj-group>
     <subject>БИОХИМИЯ И БИОТЕХНОЛОГИЯ</subject>
    </subj-group>
   </article-categories>
   <title-group>
    <article-title xml:lang="en">ОПТИМИЗАЦИЯ ТЕХНОЛОГИИ ПРОИЗВОДСТВА ВАКЦИН ПРОТИВ ЛИСТЕРИОЗА</article-title>
    <trans-title-group xml:lang="ru">
     <trans-title>ОПТИМИЗАЦИЯ ТЕХНОЛОГИИ ПРОИЗВОДСТВА ВАКЦИН ПРОТИВ ЛИСТЕРИОЗА</trans-title>
    </trans-title-group>
   </title-group>
   <contrib-group content-type="authors">
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Павленко</surname>
       <given-names>И В</given-names>
      </name>
      <name xml:lang="en">
       <surname>Павленко</surname>
       <given-names>И В</given-names>
      </name>
     </name-alternatives>
     <email>polt65@yandex.ru</email>
     <xref ref-type="aff" rid="aff-1"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Самуйленко</surname>
       <given-names>А Я</given-names>
      </name>
      <name xml:lang="en">
       <surname>Самуйленко</surname>
       <given-names>А Я</given-names>
      </name>
     </name-alternatives>
     <email>vnitibp@mail.ru</email>
     <xref ref-type="aff" rid="aff-2"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Раевский</surname>
       <given-names>А А</given-names>
      </name>
      <name xml:lang="en">
       <surname>Раевский</surname>
       <given-names>А А</given-names>
      </name>
     </name-alternatives>
     <xref ref-type="aff" rid="aff-3"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Еремец</surname>
       <given-names>В И</given-names>
      </name>
      <name xml:lang="en">
       <surname>Еремец</surname>
       <given-names>В И</given-names>
      </name>
     </name-alternatives>
     <email>biv_74@mail.ru</email>
     <xref ref-type="aff" rid="aff-4"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Нежута</surname>
       <given-names>А А</given-names>
      </name>
      <name xml:lang="en">
       <surname>Нежута</surname>
       <given-names>А А</given-names>
      </name>
     </name-alternatives>
     <email>vnitibp@mail.ru</email>
     <xref ref-type="aff" rid="aff-5"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Канарская</surname>
       <given-names>З А</given-names>
      </name>
      <name xml:lang="en">
       <surname>Канарская</surname>
       <given-names>З А</given-names>
      </name>
     </name-alternatives>
     <email>zosya_kanarskaya@mail.ru</email>
     <xref ref-type="aff" rid="aff-6"/>
    </contrib>
    <contrib contrib-type="author">
     <name-alternatives>
      <name xml:lang="ru">
       <surname>Канарский</surname>
       <given-names>А В</given-names>
      </name>
      <name xml:lang="en">
       <surname>Канарский</surname>
       <given-names>А В</given-names>
      </name>
     </name-alternatives>
     <email>alb46@mail.ru</email>
     <xref ref-type="aff" rid="aff-7"/>
    </contrib>
   </contrib-group>
   <aff-alternatives id="aff-1">
    <aff>
     <institution xml:lang="ru">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-2">
    <aff>
     <institution xml:lang="ru">ГНУ ВНИТИБП РАСХН РФ; РАСХН</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГНУ ВНИТИБП РАСХН РФ; РАСХН</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-3">
    <aff>
     <institution xml:lang="ru">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
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   </aff-alternatives>
   <aff-alternatives id="aff-4">
    <aff>
     <institution xml:lang="ru">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
    </aff>
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    <aff>
     <institution xml:lang="ru">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">ГНУ ВНИТИБП РАСХН РФ</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-6">
    <aff>
     <institution xml:lang="ru">КНИТУ</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">КНИТУ</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <aff-alternatives id="aff-7">
    <aff>
     <institution xml:lang="ru">КНИТУ</institution>
     <country>ru</country>
    </aff>
    <aff>
     <institution xml:lang="en">КНИТУ</institution>
     <country>ru</country>
    </aff>
   </aff-alternatives>
   <pub-date publication-format="print" date-type="pub" iso-8601-date="2025-08-01T13:16:05+03:00">
    <day>01</day>
    <month>08</month>
    <year>2025</year>
   </pub-date>
   <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-08-01T13:16:05+03:00">
    <day>01</day>
    <month>08</month>
    <year>2025</year>
   </pub-date>
   <volume>16</volume>
   <issue>8</issue>
   <fpage>220</fpage>
   <lpage>225</lpage>
   <history>
    <date date-type="received" iso-8601-date="2023-04-19T18:14:50+03:00">
     <day>19</day>
     <month>04</month>
     <year>2023</year>
    </date>
   </history>
   <self-uri xlink:href="https://vestniktu.ru/en/nauka/article/60857/view">https://vestniktu.ru/en/nauka/article/60857/view</self-uri>
   <abstract xml:lang="ru">
    <p>Оптимизирована технология производства сухой живой бивалентной вакцины против листериоза сельскохозяйственных животных. Выпущены опытно-промышленные партии препарата, которые прошли успешные испытания в хозяйствах.</p>
   </abstract>
   <trans-abstract xml:lang="en">
    <p>Optimized production technology of dry live bivalent vaccine against listeriosis farm animals. Produced pilot batches of the drug, which was successfully tested on farms.</p>
   </trans-abstract>
   <kwd-group xml:lang="ru">
    <kwd>Listeria monocitogenis</kwd>
    <kwd>питательная среда</kwd>
    <kwd>условия культивирования</kwd>
    <kwd>защитная среда</kwd>
    <kwd>вакцина против листериоза</kwd>
    <kwd>Listeria monocitogenis</kwd>
    <kwd>culture media</kwd>
    <kwd>culture conditions</kwd>
    <kwd>the protective environment vaccine against listeriosis</kwd>
   </kwd-group>
   <kwd-group xml:lang="en">
    <kwd>Listeria monocitogenis</kwd>
    <kwd>питательная среда</kwd>
    <kwd>условия культивирования</kwd>
    <kwd>защитная среда</kwd>
    <kwd>вакцина против листериоза</kwd>
    <kwd>Listeria monocitogenis</kwd>
    <kwd>culture media</kwd>
    <kwd>culture conditions</kwd>
    <kwd>the protective environment vaccine against listeriosis</kwd>
   </kwd-group>
  </article-meta>
 </front>
 <body>
  <p></p>
 </body>
 <back>
  <ref-list>
   <ref id="B1">
    <label>1.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">И.А. Бакулов. Мат-лы межд. симп. «Листериоз на рубеже тысячелетий». Покров. 43 - 47 (1999).</mixed-citation>
     <mixed-citation xml:lang="en">I.A. Bakulov. Mat-ly mezhd. simp. «Listerioz na rubezhe tysyacheletiy». Pokrov. 43 - 47 (1999).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B2">
    <label>2.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">В.М. Котляров. Мат-лы Межд. симп. «Листериоз на рубеже тысячелетий» Покров. 48 - 52 (1999).</mixed-citation>
     <mixed-citation xml:lang="en">V.M. Kotlyarov. Mat-ly Mezhd. simp. «Listerioz na rubezhe tysyacheletiy» Pokrov. 48 - 52 (1999).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B3">
    <label>3.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">А.Я. Самойленко Инфекционная патология животных. Часть 3. 881 с. (2009).</mixed-citation>
     <mixed-citation xml:lang="en">A.Ya. Samoylenko Infekcionnaya patologiya zhivotnyh. Chast' 3. 881 s. (2009).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B4">
    <label>4.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Р.Я. Гильмутдинов, А.В. Иванов, А.Н Панин Инфекционные болезни экзотических и диких животных. М.: Колос. 668 с. (2010).</mixed-citation>
     <mixed-citation xml:lang="en">R.Ya. Gil'mutdinov, A.V. Ivanov, A.N Panin Infekcionnye bolezni ekzoticheskih i dikih zhivotnyh. M.: Kolos. 668 s. (2010).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B5">
    <label>5.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Rocourt J., Jacguet C., Reilly A. Epidemiology of human listeriosis and seafoods// Int. J. Food Microbiol. 62 (3):197 - 209 (2000).</mixed-citation>
     <mixed-citation xml:lang="en">Rocourt J., Jacguet C., Reilly A. Epidemiology of human listeriosis and seafoods// Int. J. Food Microbiol. 62 (3):197 - 209 (2000).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B6">
    <label>6.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Schlech W.F. III; Acheson, D. (2001). &quot;Foodborne listeriosis&quot;. Clin. Infect. Dis 31 (3): 770-775. doi:10.1086/314008. PMID 11017828.</mixed-citation>
     <mixed-citation xml:lang="en">Schlech W.F. III; Acheson, D. (2001). &quot;Foodborne listeriosis&quot;. Clin. Infect. Dis 31 (3): 770-775. doi:10.1086/314008. PMID 11017828.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B7">
    <label>7.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Gray M. J., Zadoks R. N., Fortes E. D., Dogan B., Cai S., Chen Y., Scott V. N. et al. (2004). &quot;Listeria monocytogenes Isolates from Foods and Humans Form Distinct but Overlapping Populations&quot;. Applied and Environmental Microbiology 70 (10): 5833-5841. doi:10.1128/AEM.70.10.5833-5841.2004. PMC 522108. PMID 15466521.</mixed-citation>
     <mixed-citation xml:lang="en">Gray M. J., Zadoks R. N., Fortes E. D., Dogan B., Cai S., Chen Y., Scott V. N. et al. (2004). &quot;Listeria monocytogenes Isolates from Foods and Humans Form Distinct but Overlapping Populations&quot;. Applied and Environmental Microbiology 70 (10): 5833-5841. doi:10.1128/AEM.70.10.5833-5841.2004. PMC 522108. PMID 15466521.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B8">
    <label>8.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Bickley J., Short J., Mc Dowell D., Parkets H. Polymerase chain reaction detection of Listeria monocytogenes in diluted milk and resversal of PCR inhibition caused by calcium ions. // Lett. Appl. Microbiol.- 1996.- V.22. - p. 153 - 158.</mixed-citation>
     <mixed-citation xml:lang="en">Bickley J., Short J., Mc Dowell D., Parkets H. Polymerase chain reaction detection of Listeria monocytogenes in diluted milk and resversal of PCR inhibition caused by calcium ions. // Lett. Appl. Microbiol.- 1996.- V.22. - p. 153 - 158.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B9">
    <label>9.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Curts G.D. A stelective differential medium for the isolation of Listeria monocytogenes.//Lett. Appl.Microbiol. - 1989. - v.8. - p. 95 - 98.</mixed-citation>
     <mixed-citation xml:lang="en">Curts G.D. A stelective differential medium for the isolation of Listeria monocytogenes.//Lett. Appl.Microbiol. - 1989. - v.8. - p. 95 - 98.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B10">
    <label>10.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Dalton C.B., Austin C.C., Sobel J., Hayes P., Bibb W., Graves L. An Outbreak of Gastroenteritis and Fever Due to Listeria Monocytogenes in Milk. // New Engl. J. Medicine. - 1997. - V. 336. - n. 2. - p. 100 - 105.</mixed-citation>
     <mixed-citation xml:lang="en">Dalton C.B., Austin C.C., Sobel J., Hayes P., Bibb W., Graves L. An Outbreak of Gastroenteritis and Fever Due to Listeria Monocytogenes in Milk. // New Engl. J. Medicine. - 1997. - V. 336. - n. 2. - p. 100 - 105.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B11">
    <label>11.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">А.Я. Самуйленко, Е.А. Рубан. Основы биотехнологии производства биологических препаратов. М., 782с. (2000).</mixed-citation>
     <mixed-citation xml:lang="en">A.Ya. Samuylenko, E.A. Ruban. Osnovy biotehnologii proizvodstva biologicheskih preparatov. M., 782s. (2000).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B12">
    <label>12.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">И.В. Павленко Автор. дисс. канд. биол. наук. Щелково, 19 с. (2003).</mixed-citation>
     <mixed-citation xml:lang="en">I.V. Pavlenko Avtor. diss. kand. biol. nauk. Schelkovo, 19 s. (2003).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B13">
    <label>13.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">В.М. Кантере Теоретические основы технологии микробиологических производств. М., Агропромиздат. 272 с. (1991).</mixed-citation>
     <mixed-citation xml:lang="en">V.M. Kantere Teoreticheskie osnovy tehnologii mikrobiologicheskih proizvodstv. M., Agropromizdat. 272 s. (1991).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B14">
    <label>14.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">А.А. Раевский. Автореф. дисс. канд. биол. наук. Щелково, 24 с. (2002).</mixed-citation>
     <mixed-citation xml:lang="en">A.A. Raevskiy. Avtoref. diss. kand. biol. nauk. Schelkovo, 24 s. (2002).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B15">
    <label>15.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Скотникова Т.А., Неминущая Л.А., Еремец Н.К., Провоторова О.В., Бобровская И.В., Малышева М.А., З.А. Канарская. Вестник Каз. технол. ун. Т. 15. № 4. с. 82 - 87. (2012).</mixed-citation>
     <mixed-citation xml:lang="en">Skotnikova T.A., Neminuschaya L.A., Eremec N.K., Provotorova O.V., Bobrovskaya I.V., Malysheva M.A., Z.A. Kanarskaya. Vestnik Kaz. tehnol. un. T. 15. № 4. s. 82 - 87. (2012).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B16">
    <label>16.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Неминущая Л.А., Скотникова Т.А., Титова Е.И., Провоторова О.В., Еремец Н.К., Бобровская И.В., З.А. Канарская. Вестник Каз. технол. ун. Т. 15. № 4.с. 69 - 74. (2012).</mixed-citation>
     <mixed-citation xml:lang="en">Neminuschaya L.A., Skotnikova T.A., Titova E.I., Provotorova O.V., Eremec N.K., Bobrovskaya I.V., Z.A. Kanarskaya. Vestnik Kaz. tehnol. un. T. 15. № 4.s. 69 - 74. (2012).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B17">
    <label>17.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">И.В.Павленко, А.Я. Самуйленко, В.И. Еремец, И.В. Бобровская, А.А. Нежута, З.А. Канарская, А.В. Канарский Вестник Каз. технол. ун. Т. 15. № 7. с. 82 -87. (2013).</mixed-citation>
     <mixed-citation xml:lang="en">I.V.Pavlenko, A.Ya. Samuylenko, V.I. Eremec, I.V. Bobrovskaya, A.A. Nezhuta, Z.A. Kanarskaya, A.V. Kanarskiy Vestnik Kaz. tehnol. un. T. 15. № 7. s. 82 -87. (2013).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B18">
    <label>18.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Патент РФ № 2080379 (1997).</mixed-citation>
     <mixed-citation xml:lang="en">Patent RF № 2080379 (1997).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B19">
    <label>19.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Патент РФ № 2080380 (1997).</mixed-citation>
     <mixed-citation xml:lang="en">Patent RF № 2080380 (1997).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B20">
    <label>20.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">В.В. Бирюков, В.М. Кантере. Оптимизация периодических процессов микробиологического синтеза. М. Наука. 293с. (1985).</mixed-citation>
     <mixed-citation xml:lang="en">V.V. Biryukov, V.M. Kantere. Optimizaciya periodicheskih processov mikrobiologicheskogo sinteza. M. Nauka. 293s. (1985).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B21">
    <label>21.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">А.Я. Самуйленко, И.В, Павленко, А.А. Раевский, Л.В. Анисимова, Л.Б. Соловьев, В.И. Еремец, В.В. Меньшенин, А.А. Нежута. Ветеринарная медицина. 95 Международный тематический научный сборник. Харьков. С. 181 - 182 (2011).</mixed-citation>
     <mixed-citation xml:lang="en">A.Ya. Samuylenko, I.V, Pavlenko, A.A. Raevskiy, L.V. Anisimova, L.B. Solov'ev, V.I. Eremec, V.V. Men'shenin, A.A. Nezhuta. Veterinarnaya medicina. 95 Mezhdunarodnyy tematicheskiy nauchnyy sbornik. Har'kov. S. 181 - 182 (2011).</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B22">
    <label>22.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">Fran Lowry (2008-05-15). &quot;Live Listeria Vaccine Proves Safe Against End-Stage Cervical Ca in Human Trial&quot;. Ob.Gyn. News Vol.43, No.10, page 2.</mixed-citation>
     <mixed-citation xml:lang="en">Fran Lowry (2008-05-15). &quot;Live Listeria Vaccine Proves Safe Against End-Stage Cervical Ca in Human Trial&quot;. Ob.Gyn. News Vol.43, No.10, page 2.</mixed-citation>
    </citation-alternatives>
   </ref>
   <ref id="B23">
    <label>23.</label>
    <citation-alternatives>
     <mixed-citation xml:lang="ru">И.В. Павленко, А.А. Раевский, А.А.Нежута, А.Я. Дадасян Известия Самарского научного центра Росс. Акад. Наук. Самара. Изд-во самарского научного центра РАН. Т. 13, № 5(3). С. 171 - 174 (2011).</mixed-citation>
     <mixed-citation xml:lang="en">I.V. Pavlenko, A.A. Raevskiy, A.A.Nezhuta, A.Ya. Dadasyan Izvestiya Samarskogo nauchnogo centra Ross. Akad. Nauk. Samara. Izd-vo samarskogo nauchnogo centra RAN. T. 13, № 5(3). S. 171 - 174 (2011).</mixed-citation>
    </citation-alternatives>
   </ref>
  </ref-list>
 </back>
</article>
