Herald of Technological University Herald of Technological University ВЕСТНИК ТЕХНОЛОГИЧЕСКОГО УНИВЕРСИТЕТА 3034-4689 62607 БИОХИМИЯ, БИОТЕХНОЛОГИЯ И ЭКОЛОГИЯ БИОХИМИЯ, БИОТЕХНОЛОГИЯ И ЭКОЛОГИЯ BACTERIAL POLY(3-HYDROXYBUTYRATE) AS A BIODEGRADABLE POLYMER FOR BIOMEDICINE. PART 1 Iordanskii A L Iordanskii A L Bonartseva G A Bonartseva G A Makhina T A Makhina T A Sklyanchuk E D Sklyanchuk E D Zaikov G E Zaikov G E ov_stoyanov@mail.ru N. Semenov Institute of Chemical Physics, RAS, Kosygin str. 4, Moscow. 119996 RF and A.N. Bach’s Institute of Biochemistry ru N. Semenov Institute of Chemical Physics, RAS, Kosygin str. 4, Moscow. 119996 RF and A.N. Bach’s Institute of Biochemistry ru N. Bach’s Institute of Biochemistry ru N. Bach’s Institute of Biochemistry ru A.N. Bach’s Institute of Biochemistry ru A.N. Bach’s Institute of Biochemistry ru Center of Traumatology and Orthopaedy, Moscow ru Center of Traumatology and Orthopaedy, Moscow ru N. Emanuel Institue of Biochemical Physics ru N. Emanuel Institue of Biochemical Physics ru 01 08 2025 01 08 2025 17 4 204 213 20 04 2023 https://vestniktu.ru/en/nauka/article/62607/view

Бактериальный поли (3-оксибутират) (ПГБ) как представитель семейства природных полимеров полиалканоатов широко используется в инновационных биомедицинских областях благодаря соответствующей комбинации биосовместимости, транспортных характеристик и биоразлагаемости без образования токсических продуктов. В обзоре представлено всестороннее описание гидролиза и ферментативного расщепления в течении длительного периода времени предпочтительно в лабораторных условиях (in vitro) и как медицинских имплантов (в естественных условиях). Кроме того, обзор посвящен сравнению литературы в области разложения ПГБ и его биомедицинского применения, включая работы авторов обзора.

Bacterial poly(3-hydroxybutyrate) (PHB) as member of natural polymer family of polyalcanoates has been widely used in the innovative biomedical areas owing to relevant combination of biocompatibility, transport characteristics and biodegradation without toxic products’ formation. The review presents a comprehensive description of hydrolysis and enzymatic degradation during long-time period preferably under laboratory condition (in vitro) and as medical implants (in vivo). Besides, the focus of review is devoted to the literature comparison of different works in PHB degradation and its biomedical application including work of authors.

 поли (3-оксибутират) биоразлагаемость неэнзиматический гидролиз биомедицинские системы потеря массы поверхностное разложение poly(3-hydroxybutyrate) biodegradability nonenzymatic hydrolysis biomedical applications weight loss surface degradation поли (3-оксибутират) биоразлагаемость неэнзиматический гидролиз биомедицинские системы потеря массы поверхностное разложение poly(3-hydroxybutyrate) biodegradability nonenzymatic hydrolysis biomedical applications weight loss surface degradation

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