Работа посвящена биоразлагаемому поли(3-гидроксибутирату) и исследованию его производных. Исследована кинетика гидролитического разложения при 37 и 70 oС в фосфатном буфере для сравнения кинетических профилей ПЛЛ и ПГБ. Кроме того, изучена кинетика для сополимера ПГБВ (20% 3-гидроксивалерата) и смеси ПГБ-ПЛЛ. Интенсивность гидролиза биополимера характеризуется общей потерей массы и уменьшением усредненной молекулярной массы (MМ). Разложение усиливается в серии ПГБВ <ПГБ< смесь ПГБ-ПЛЛ
Bacterial poly(3-hydroxybutyrate), copolymer PHBV, polylactide, PHB-PLA blend, non-enzymatic hydrolysis, role of molecular weight, crystallinity, total weight loss, WAXS, AMF, бактериальный поли(3-гидроксибутират), сополимер ПГБВ, полилактид, смесь ПГБ-ПЛЛ, без-ферментативный гидролиз, роль молекулярной массы, кристалличность, общая потеря массы, метод WAXS, АСМ
1. Sudesh, K., Abe, H., Doi, Y. Synthesis, structure and properties of polyhy-droxyalkanoates: Biological polyesters. Progress in Polymer Science (Oxford), 2000, 25 (10): 1503-1555.
2. Lenz R.W., Marchessault R.H. Bacterial Polyesters: Biosynthesis, Biodegradable Plastics and Biotechnology. Biomacromolecules, 2005, 6(1): 1-8.
3. Bonartsev A.P., Iordanskii A.L., Bonartseva G.A. and Zaikov G.E. Biodegradation and Medical Application of Microbial Poly (3-Hydroxybutyrate). Polymers Research Journal, 2008, 2(2): 127-160
4. Kadouri, D., Jurkevitch, E., Okon, Y., Castro-Sowinski, S. Critical Reviews in Microbiology 31 (2), pp. 55-67 (2005) Ecological and agricultural significance of bacterial polyhydroxyalkanoates.
5. Jendrossek D., Handrick R. Microbial degradation of polyhydroxyalkanoates. Annu Rev Microbiol. 2002; 56: 403-432.
6. Steinbuchel, A. and Lutke-Eversloh, T. Metabolic engineering and pathway construction for biotechnological production of relevant poly-hydroxyalkanoates in microorganisms. Biochem. Eng. J. 2003;16: 81-96.
7. Miller N.D, Williams D.F. On the biodegradation of poly-beta-hydroxybutyrate (PHB) homopolymer and poly-beta-hydroxybutyrate-hydroxyvalerate copolymers. Biomaterials. 1987, 8(2):129-137.
8. Qu XH, Wu Q, Zhang KY, Chen GQ. In vivo studies of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) based polymers: biodegradation and tissue reactions. Biomaterials. 2006; 27(19):3540-3548
9. L.J.R. Fostera, V. Sanguanchaipaiwonga, C.L. Gabelisha, J. Hookc, M. Stenzel. A natural-synthetic hybrid copolymer of polyhydroxyoctanoate-diethylene glycol: biosynthesis and properties. Polymer 2005; 46: 6587-6594
10. Marois, Y., Zhang, Z., Vert, M., Deng, X., Lenz, R., Guidoin, R. Mechanism and rate of degradation of polyhydroxyoctanoate films in aqueous media: A long-term in vitro study. Journal of Biomedical Materials Research, 2000; 49 (2): 216-224.
11. Freier T., Kunze C., Nischan C., Kramer S., Sternberg K., Sass M., Hopt U.T., Schmitz K.-P. In vitro and in vivo degradation studies for development of a biodegradable patchbased on poly(3-hydroxybutyrate). Biomaterials, 2002, 23; 2649-2657.
12. Doi Y, Kanesawa Y, Kawaguchi Y, Kunioka M. Hydrolytic degradation of microbial poly(hydroxyalkanoates). Makrom Chem Rapid Commun 1989;10:227-230.
13. Renstadt R, Karlsson S, Albertsson A.C. The influence of processing conditions on the properties and the degradation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Macromol Symp. 1998; 127: 241-249.
14. Cheng Mei-Ling, Chen Po-Ya, Lan Chin-Hung, Sun Yi-Ming. Structure, mechanical properties and degradation behaviors of the electrospun fibrous blends of PHBHHx/PDLLA. Polymer 2011, doihttps://doi.org/10.1016/j.polymer.2011.01.039 in press.
15. Myshkina V.L., Nikolaeva D.A., Makhina T.K., Bonartsev A.P., and Bonartseva G.A. Effect of Growth conditions on the Molecular weight of poly-3-hydroxybutyrate produced by Azotobacter chroococcum 7B. Applied Biochemistry and Microbiology, 2008, 44(5): 482-486.
16. Myshkina V. L., Ivanov E. A., Nikolaeva D. A., Makhina T. K., Bonartsev A. P., Filatova E. V., Ruzhitsky A. O., and Bonartseva G. A. Biosynthesis of Poly-3-Hydroxybutyrate-3-Hydroxyvalerate Copolymer by Azotobacter chroococcum Strain 7B. Applied Biochemistry and Microbiology, 2010, 46(3): 289-296.
17. Akita S., Einaga Y., Miyaki Y., Fujita H. Solution Properties of Poly(D-β-hydroxybutyrate). 1. Biosynthesis and Characterization. Macromolecules. 1976: 9: 774-780.
18. Rebrov A.V., Dubinskii V.A., Nekrasov Y.P., Bonartseva G.A., Shtamm M., Antipov E.M. [Structure phenomena at elastic deformation of highly oriented polyhydroxybutyrate. Polymer Science (Russian) 2002, 44A, 347-351
19. Koyama N. and Doi Y. Morphology and biodegradability of a binary blend of poly((R)-3-hydroxybutyric acid) and poly((R,S)-lactic acid). Can. J. Microbiol., 1995, 41(Suppl. 1): 316-322.
20. Majid M.I.A., Ismail J., Few L.L. and Tan C.F. The degradation kinetics of poly(3-hydroxybutyrate) under non-aqueous and aqueous conditions. European Polymer Journal. 2002; 38(4): 837-839.
21. Choi G.G., Kim H.W., Rhee Y.H. Enzymatic and non-enzymatic degradation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolyesters produced by Alcaligenes sp. MT-16. The Journal of Microbiology, 2004, 42(4): 346-352.
22. Iordanskii A.L., Rudakova T.E., Zaikov G.E. Interaction of polymers with corrosive and bioactive media. 1984, VSP, New York -Tokyo
23. Wang H.T., Palmer H., Linhardt R.J., Flanagan D.R., Schmitt E. Degradation of poly(ester) microspheres. Biomaterials. 1990; 11(9):679-685.
24. Kurcok P., Kowalczuk M., Adamus G., Jedlinґski Z., Lenz R.W. Degradability of poly (b-hydroxybutyrate)s. Correlation with chemical microstucture. JMS-Pure Appl. Chem. 1995, A32: 875-880.
25. Reusch R.N. Biological complexes of poly-β-hydroxybutyrate. FEMS Microbiol. Rev., 1992, 103: 119-130.
26. Molnár K., J. Móczó, M. Murariu, Ph. Dubois, B. Pukánszky. Factors affecting the properties of PLA/CaSO4 composites: homogeneity and interactions. eXPRESS Polymer Letters Vol.3, No.1 (2009) 49-61
27. Spyros A., Kimmich R., Briese B., Jendrossek D. 1H NMR imaging study of enzymatic degradation in poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Evidence for preferential degradation of amorphous phase by PHB depolymerase B from Pseudomonas lemoignei. Macromolecules. 1997; (30): 8218-8225.
28. Luizier W. D. Materials derived from biomass/biodegradable materials. Proc. Natl. Acad. Sci. USA. 1992; (89): 839-842.
29. Gao Y, Kong L, Zhang L, Gong Y, Chen G, Zhao N, et al. Eur Polym J 2006; 42 (4):764-75.
30. Pompe T., Keller K., Mothes G., Nitschke M., Teese M., Zimmermann R., Werner C. Surface modification of poly(hydroxybutyrate) films to control cell-matrix adhesion. Biomaterials. 2007, 28(1): 28-37.
31. Siepmann J, Siepmann F. and Florence A.T. Local controlled drug delivery to the brain: Mathematical modeling of the underlying mass transport mechanisms. International Journal of Pharmaceutics, 2006; 314(2), 101-119.
32. Zhang T.C., Fu Y.C., Bishop P.L. et al. Transport and biodegradation of toxic organics in biofilms. Journal of Hazardous Materials, 1995; 41(2-3): 267-285.
