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Herald of Technological University
Journals / Herald of Technological University / Volume 29 Issue 7 / MODIFICATION OF POLYLACTIDE AND POLYLACTIDE-HYDROXYAPATITE MATRICES BY IMPREGNATION OF LIDOCAINE HYDROCHLORIDE IN A SUPERCRITICAL CARBON DIOXIDE ENVIRONMENT

MODIFICATION OF POLYLACTIDE AND POLYLACTIDE-HYDROXYAPATITE MATRICES BY IMPREGNATION OF LIDOCAINE HYDROCHLORIDE IN A SUPERCRITICAL CARBON DIOXIDE ENVIRONMENT

Published in Herald of Technological University · Volume 29, Issue 7 · Pages 80–85 · Rubric: 2. Chemical Technology
DOI: https://doi.org/10.55421/3034-4689_2026_29_7_80 · EDN: KAGDTK
Received: 24.03.2026 Accepted: 28.06.2026 Published: 30.07.2026
Authors
E.
E. K. Rastegaev
IL
Il'nur Gil'mutdinov
A
A N Sabirzyanov
ABSTRACT
This paper presents a study for modifying biocompatible polymer matrices based on polylactic acid (PLA) and its composites with hydroxyapatite (HAP) through the impregnation of lidocaine hydrochloride in a supercritical carbon dioxide environment. The relevance of the research is determined by the need to develop new biocomposite materials for implant medicine that combine high biocompatibility with a prolonged therapeutic effect. The aim of the work is to study the effectiveness of the process of impregnating medicinal substances into polymer matrices under supercritical conditions. During the research, the patterns of lidocaine hydrochloride dissolution in a supercritical CO₂ environment at various thermodynamic parameters were studied. Modification was carried out on both pure polylactic matrices and PLA/HAP composite materials (mass ratio 70/30). The experiments included determining the optimal impregnation conditions and investigating the effect of pressure and temperature on the degree of matrix saturation with lidocaine hydrochloride. It was established that the maximum impregnation efficiency is achieved at a pressure of 35 MPa. It was shown that PLA/HAP composite materials demonstrate a higher ability to retain the medicinal substance compared to pure PLA matrices. It was revealed that with an increase in the duration of contact with the solvent, the degree of lidocaine release increases, reaching a maximum at a 24-hour exposure. The practical significance of the work lies in the development of technology for producing biocompatible implants with controlled anesthetic release, which can be applied in traumatology and orthopedics to reduce postoperative pain. The results obtained expand the possibilities of creating a new generation of biocomposite materials with specified properties for regenerative medicine.
KEYWORDS
SOLUBILITY, IMPREGNATION, POLYMERS, SUPERCRITICAL CARBON DIOXIDE
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1. R.B. Gupta, J.J. Shim, *Solubility in Supercritical Carbon Dioxide*. CRC Press, 2006. DOI: https://doi.org/10.1201/9781420005998

2. A. Jouyban, H.K. Chan, N.R. Foster, *The Journal of Supercritical Fluids*, 24, 1, 19–35 (2002).

3. D.Yu. Zalepugin, N.A. Tilkunova, I.V. Chernyshova, “Supercritical Fluids: Theory and Practice,” 14, 3, 11–25 (2019).

4. D.Yu. Zalepugin, “Supercritical Fluids: Theory and Practice, 4, 56–64 (2008).

5. D.A. Lemenovsky, V.N. Bagrataashvili, Soros Educational Journal, 310, 145 (1999).

6. A.W. Kjellow, O. Henriksen, The Journal of Supercritical Fluids, 50, 3, 297–304 (2009). DOI: https://doi.org/10.1016/j.supflu.2009.06.013

7. I.R. Mugtasimov, E.K. Rastegaev, I.V. Kuznetsova, A.N. Sabirzyanov, Proceedings. KNITU, 194–197 (2022).

8. E.K. Rastegaev, I.I. Gilmutdinov, I.V. Kuznetsova, A.N. Sabirzyanov, Bulletin of the A.N. Tupolev Kazan State Technical University, 78, 3, 58–64 (2022).

9. E.K. Rastegaev, I.I. Gilmutdinov, N.S. Sandugei, I.V. Kuznetsova, A.N. Sabirzyanov, *Journal of Physics: Conference Series*, 1–7 (2023).

10. I.V. Kuznetsova, E.K. Rastegaev, I.M. Gilmutdinov, I.I. Gilmutdinov, A.N. Sabirzyanov, New Polymer Composite Materials. Mikitaev Readings: Collection of Abstracts, 229 (2023).

11. E.K. Rastegaev, I.V. Kuznetsova, I.I. Gilmutdinov, A.N. Sabirzyanov, “Supercritical Fluids: Fundamental Principles, Technologies, Innovations: Collection of Abstracts,” 459–461 (2023).

12. E.K. Rastegaev, I.I. Gilmutdinov, I.V. Kuznetsova, A.N. Sabirzyanov, Bulletin of the Technological University, 26, 11, 155–159 (2023). DOI: https://doi.org/10.55421/1998-7072_2023_26_11_155

13. E.K. Rastegaev, I.V. Kuznetsova, I.I. Gilmutdinov, A.N. Sabirzyanov, Proceedings of the VII All-Russian Student Scientific and Technical Conference, KNITU, 446 (2024).

14. E.K. Rastegaev, I.V. Kuznetsova, M. Akplogan, A.N. Sabirzyanov, Proceedings of the 1st All-Russian Student Scientific and Technical Conference “Equipment and Technological Processes of Heating and Refrigeration Systems,” KNITU, 142–144 (2024).

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