RELEASE OF PLANT EXTRACTS FROM NANOMODIFIED POLYMERIC GELS
Rubrics: 2. CHEMICAL TECHNOLOGY
Authors:
1.
KNITU
2.
Kazanskiy institut biohimii i biofiziki FIC KazNC RAN
3.
KNITU
Type:
Article
Pages:
from 101
to 106
Status:
Published
Received:
22.12.2025
Accepted:
23.12.2025
Published:
23.12.2025
Language:
Russian
Keywords:
FULLERENE C60, NONIONIC SURFACTANTS, POLYMER GELS, VISCOSITY, ELECTRICAL CONDUCTIVITY, RELEASE, ANTIOXIDANT ACTIVITY
Abstract (English):
Gel-based compositions are widely used in medicine and cosmeceutics as effective platforms for the transdermal delivery of pharmaceuticals and biologically active substances (BAS) into the human body. The electrical conductivity and rheological properties of gels can be significantly improved by introducing fullerene C60 and ensuring its uniform distribution within the gel matrix. In this regard, the aim of this work is to modify the rheological and conductive characteristics of gels based on lightly cross-linked polyacrylic acid by incorporating dispersions of fullerene C60 for the electrophoretic release of plant extracts. Aqueous C60 dispersions were prepared by ultrasonic treatment of the carbon nanomaterial in water as well as in aqueous solutions of ethoxylated higher fatty alcohols, Poloxamer-184, and Tween-80. The rheological properties of the resulting gels were studied using rotational viscometry. It was demonstrated that the incorporation of fullerene C60 dispersions with nonionic surfactants into the gel composition leads to a decrease in system viscosity. The electrical conductivity of the gels was evaluated by conductometric measurements; it was found that the introduction of fullerene into the gel composition increases the conductivity by a factor of 2,2-2,8. Moreover, the release of honeysuckle extract from gels containing fullerene C60 and nonionic surfactants under electrophoresis was 1,6-3,6 times higher compared to the base gel. These findings suggest that Carbomer 141G-based gels enriched with C60 dispersions represent promising transdermal carriers for therapeutic and biologically active substances. As a result, an electrically conductive cosmetic gel containing fullerene C60 with antioxidant properties was developed.
Gel-based compositions are widely used in medicine and cosmeceutics as effective platforms for the transdermal delivery of pharmaceuticals and biologically active substances (BAS) into the human body. The electrical conductivity and rheological properties of gels can be significantly improved by introducing fullerene C60 and ensuring its uniform distribution within the gel matrix. In this regard, the aim of this work is to modify the rheological and conductive characteristics of gels based on lightly cross-linked polyacrylic acid by incorporating dispersions of fullerene C60 for the electrophoretic release of plant extracts. Aqueous C60 dispersions were prepared by ultrasonic treatment of the carbon nanomaterial in water as well as in aqueous solutions of ethoxylated higher fatty alcohols, Poloxamer-184, and Tween-80. The rheological properties of the resulting gels were studied using rotational viscometry. It was demonstrated that the incorporation of fullerene C60 dispersions with nonionic surfactants into the gel composition leads to a decrease in system viscosity. The electrical conductivity of the gels was evaluated by conductometric measurements; it was found that the introduction of fullerene into the gel composition increases the conductivity by a factor of 2,2-2,8. Moreover, the release of honeysuckle extract from gels containing fullerene C60 and nonionic surfactants under electrophoresis was 1,6-3,6 times higher compared to the base gel. These findings suggest that Carbomer 141G-based gels enriched with C60 dispersions represent promising transdermal carriers for therapeutic and biologically active substances. As a result, an electrically conductive cosmetic gel containing fullerene C60 with antioxidant properties was developed.
Keywords:
FULLERENE C60, NONIONIC SURFACTANTS, POLYMER GELS, VISCOSITY, ELECTRICAL CONDUCTIVITY, RELEASE, ANTIOXIDANT ACTIVITY
FULLERENE C60, NONIONIC SURFACTANTS, POLYMER GELS, VISCOSITY, ELECTRICAL CONDUCTIVITY, RELEASE, ANTIOXIDANT ACTIVITY
