MAGNETITE NANOPARTICLES FUNCTIONALIZATION WITH CHITOSAN-CARRAGEENAN POLYELECTROLYTE COMPLEX
Rubrics: 2. CHEMICAL TECHNOLOGY
Authors:
1.
KNITU; KNRTU
2.
Kazan National Research Technological University
Type:
Article
Pages:
from 73
to 78
Status:
Published
Received:
03.02.2026
Accepted:
26.02.2026
Published:
05.04.2026
Language:
Russian
Keywords:
MAGNETITE, MAGNETIC NANOPARTICLES, CHITOSAN, CARRAGEENAN, POLYELECTROLYTE COMPLEX
Funding:
Issledovanie vypolneno v ramkah Gosudarstvennogo zadaniya № 075-00021-26-00 ot 12.01.2026 (FZSG-2026-0003).
Abstract:
Magnetite nanoparticles modified with a polyelectrolyte complex of the aminopolysaccharide chitosan with the sulfated polysaccharide κ-carrageenan were obtained. The surface of iron oxide Fe3O4 particles was functionalized with chitosan and carrageenan via hydrothermal treatment and chemical coprecipitation. Optimal conditions for nanoparticle modification were selected, including temperature, treatment time, polysaccharide concentrations and their ratio in the system, the presence of a cross-linking agent (glutaraldehyde), and the type of solvent. The presence of a characteristic band (570 cm-1) in the IR spectra of the original and modified Fe3O4 particles, caused by the stretching vibrations of the Fe-O bond in octahedral complexes, was established. The spectra of the modified magnetite particles contain absorption bands characteristic of the functional groups of chitosan and κ-carrageenan, confirming the successful functionalization of the iron oxide particle surface. Dynamic light scattering demonstrated that the original magnetite particles exhibit a high tendency to self-aggregate in aqueous media. Modifying the surface of Fe3O4 particles with the chitosan-κ-carrageenan complex reduced the average hydrodynamic size of the associates, a trend that was maintained across all modification methods. In the presence of the polyelectrolyte complex, the surface charge of the magnetic nanoparticles became positive, satisfying the conditions for electrostatic stabilization of the nanoparticles in suspension. Surface modification of Fe3O4 particles was shown to reduce their magnetic sensitivity, but magnetite particles functionalized with the polysaccharide complex retained their magnetic properties. The resulting modified Fe3O4 iron oxide nanoparticles can be considered promising carriers for the targeted delivery of therapeutically active substances due to their sensitivity to an external magnetic field.
Magnetite nanoparticles modified with a polyelectrolyte complex of the aminopolysaccharide chitosan with the sulfated polysaccharide κ-carrageenan were obtained. The surface of iron oxide Fe3O4 particles was functionalized with chitosan and carrageenan via hydrothermal treatment and chemical coprecipitation. Optimal conditions for nanoparticle modification were selected, including temperature, treatment time, polysaccharide concentrations and their ratio in the system, the presence of a cross-linking agent (glutaraldehyde), and the type of solvent. The presence of a characteristic band (570 cm-1) in the IR spectra of the original and modified Fe3O4 particles, caused by the stretching vibrations of the Fe-O bond in octahedral complexes, was established. The spectra of the modified magnetite particles contain absorption bands characteristic of the functional groups of chitosan and κ-carrageenan, confirming the successful functionalization of the iron oxide particle surface. Dynamic light scattering demonstrated that the original magnetite particles exhibit a high tendency to self-aggregate in aqueous media. Modifying the surface of Fe3O4 particles with the chitosan-κ-carrageenan complex reduced the average hydrodynamic size of the associates, a trend that was maintained across all modification methods. In the presence of the polyelectrolyte complex, the surface charge of the magnetic nanoparticles became positive, satisfying the conditions for electrostatic stabilization of the nanoparticles in suspension. Surface modification of Fe3O4 particles was shown to reduce their magnetic sensitivity, but magnetite particles functionalized with the polysaccharide complex retained their magnetic properties. The resulting modified Fe3O4 iron oxide nanoparticles can be considered promising carriers for the targeted delivery of therapeutically active substances due to their sensitivity to an external magnetic field.
Keywords:
MAGNETITE, MAGNETIC NANOPARTICLES, CHITOSAN, CARRAGEENAN, POLYELECTROLYTE COMPLEX
MAGNETITE, MAGNETIC NANOPARTICLES, CHITOSAN, CARRAGEENAN, POLYELECTROLYTE COMPLEX
