This study assessed the feasibility of controlling the properties of wound-healing wraps based on a polymer mixture of sodium N-succinyl chitosan, sodium carboxymethyl cellulose, and glycerin, cryostructured via freeze-drying, by varying the processing conditions and the qualitative and quantitative composition of the mixtures. The relevance of the work is due to the fact that wound-healing coatings based on biodegradable and biocompatible polymers such as chitosan, cellulose, or their functional derivatives, which are permeable to air and impermeable to bacteria, can be used for the prolonged delivery of antimicrobial drugs to the wound site. In particular, sodium N-succinyl chitosan, in addition to the above-mentioned advantages, has antimicrobial properties, coagulation activity, and the ability to counteract scar formation. The possibility of controlling the physicomechanical properties of porous materials based on mixtures of 3% by weight of sodium N-succinyl chitosan and 1.5% by weight of sodium carboxymethyl cellulose by varying the lyophilization conditions of the molding solutions is demonstrated. It was established that the optimal complex is characteristic of materials obtained under conditions of slow cooling during the cryostructuring stage and slow heating during the freeze-drying stage. A promising wound-healing coating in the form of porous plates obtained by lyophilization from initial solutions of 3% by weight of sodium N-succinyl chitosan, 1.5% by weight of sodium carboxymethyl cellulose, 1% by weight of glycerol is proposed. It surpasses materials based on individual sodium N-succinyl chitosan and the commercially available analogue "Khitokol-DA" in terms of tensile strength by an average of 40-160% and elasticity by 200-370%.
SODIUM N-SUCCINYL CHITOSAN, SODIUM CARBOXYMETHYL CELLULOSE, GLYCERIN, FREEZE-DRYING, PHYSICOMECHANICAL PROPERTIES
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