graduate student from 01.01.2022 until now
Russian Federation
Kazanskiy Fiziko-Tehnicheskiy Institut im. E.K. Zavoyskogo FIC KazNC RAN
Russian Federation
In modern biomedicine, increasing attention is being paid to the development of theranostic systems that combine drug delivery with the ability to visualize their distribution and release. Among various types of carriers, lyotropic liquid crystalline (LLC) systems occupy a special place due to their ability to encapsulate both hydrophilic and hydrophobic substances and provide controlled release. Additional opportunities are opened by the introduction of luminescent nanoparticles into such systems, acting as optical labels. In this work, a comparative study of two LLC systems based on the nonionic surfactant C12EO8 containing 1 wt.% xymedone as a model drug was carried out. Using polarized optical microscopy and differential scanning calorimetry, it was found that the introduction of carbon dots reduces the phase transition temperature to the isotropic state. The calculated thermodynamic characteristics of the phase transitions for the lyomesophases indicate a decrease in thermal effects for the modified media. Release studies using Franz diffusion cells showed that the system without carbon dots exhibits prolonged release of xymedone in water, whereas the system with the luminophore exhibits faster release. Luminescent monitoring confirmed that the carbon dots retain their emission properties throughout the experiment, allowing real-time tracking of the system. Xymedone also possesses its own luminescence, providing a dual optical response. Thus, the studied systems represent two complementary theranostic strategies: prolonged release without an additional optical label and faster release with built-in luminescent monitoring. The choice of delivery method is determined by the specific therapeutic task.
LYOTROPIC LIQUID CRYSTALS, CARBON DOTS, HYBRID LYOTROPIC MEDIA, C12EO8, XYMEDONE, RELEASING
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