We tested the action of Melafen in animal cells and its components under a wide range of concentrations (10 -17 - l0 -3). The changes in structural organization of microdomains in multulammelar liposomes from individual phospholipid DMPC were found. The lipid phase in membrane is susceptible to Melafen influence. However in structural organization of protein-lipid microdomains - in erythrocyte ghosts, being by the adequate model of cell membrane for most of cells, significant effects were absent. The structural change of soluble protein – bovine serum albumin in the presence of large concentrations of Melafen (10 -8 - 10 -4 M) were found, the structure BSA was loosened. However, when we tested the influence of Melafen on the cell functioning, the concentration non-destructive interval was being narrowed. Changes are seen already at concentrations of 10-11 - 10 -13 М.
мелафен, липосомы, тени эритроцитов, ДСК, БСА, melafen, liposomes, ghost of erythrocytes, DSC, BSA
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