Studied toxic and mutagenic effects of various derivatives of furanones on bacterial cells. Shown hypertoxic effects for furanone № 6 and mutagenic effects of furanone № 1 of the two groups of compounds represented . It is planned to further study the biological activity of the investigated derivatives of furanones.
галогенированные фураноны, токсичность, мутагенность, кворум-зависимые процессы, halogenated furanones, toxicity, mutagenicity, the quorum-sensing processes
1. Zayceva, Yu. V. Molekulyarno-geneticheskie osobennosti Quorum Sensing sistem gramotricatel'nyh bakteriy (na modeli Serratia) i izuchenie ih roli v regulyacii kletochnyh processov [Tekst] : avtoref. dis. kand. biol. nauk / Yu. V. Zayceva ; Federal'noe gosudarstvennoe byudzhetnoe uchrezhdenie nauki Institut molekulyarnoy genetiki RAN - Moskva, 2012. - 24 s.
2. Manefield, M. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein [Text] / M. Manefield, R. de Nys, N. Kumar, R. Read, M. Givskov, P. Steinberg, S. Kjelleberg // Microbiology - 1999. V.145, P. 283-291.
3. Martinelli, D. Effects of natural and chemically synthesized furanones on quorum sensing in Chromobacterium violaceum [Text] / D. Martinelli, G. Grossmann, U. Sequin, H. Brandl, R. Bachofen // BMC Microbiology - 2004. No.4, V.25.
4. Manefield, M. Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover [Text] / M. Manefield, T.B. Rasmusen, M. Hentzer, J.B. Anderson, P. Steinberg, S. Kjelleberg, M. Givskov // Microbiology - 2002. V.148, P.1119-1127.
5. Hentzer, M. Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections [Text] / M. Hentzer, M. Givskov // J. Clin. Invest - 2003. V.112, P. 1300-1307.
6. Gimadeeva, R.M. Citotoksichnost' i genotoksichnost' novyh proizvodnyh furanona / R.M.Gimadeeva, E.V.Babynin, A.B.Margulis // "Vestnik Ural'skoy medicinskoy akademicheskoy nauki" (Tematicheskiy vypusk po mikrobiologii, immunologii i biotehnologii).- 2011.- №4/1(38).- S. 26.
7. Margulis, A.B. Vliyanie hlorproizvodnyh 2(5N)-furanona na zhiznesposobnost' bakterial'nyh kletok / A.B.Margulis, A.R.Kurbangalieva, N.V.Belonogova, L.Z.Latypova, V.Ya.Ponomarev, E.N.Hakimullina, E.Yu.Trizna, M.I.Bogachev, A.R.Kayumov // Vestnik Kazanskogo tehnologicheskogo universiteta.- 2012.- T. 15, №15.- S. 220-224.
8. Margulis, A.B. Metody geneticheskoy toksikologii / A.B. Margulis, N.S. Karamova, O.N. Il'inskaya // Uchebno-metodicheskoe posobie.- Kazan': KFU, 2012.- 36 s.