The synthesis of new biologically active compounds possessing new properties and the creation on their base of new drugs with complex of properties for the treatment and prevention of various diseases is one of the major problems in modern organic, bioorganic and medicinal chemistry. Benzofuroxan which find use as antiparasitic, antifungal , antibacterial drugs in veterinary, medicine and agriculture occupy an important place in the variety of compounds with high biological activity [1 , 2]. With the aim of synthesis of new benzofuroxan derivatives we realized interaction of 7-chloro-4,6-dinitrobenzofuroxan with different amino acids.
7-хлоро-4,6-динитробензофуроксан,, аминокислоты, 7-chloro-4,6-dinitrobenzofuroxan, amino acid
1. Timasheva R.E., Chugunova E.A., Gibadullina E.M., Burilov A.R., Buharov S.V. Proizvodnye bis(4-aminofenilovogo) efira, soderzhaschie benzofuroksanovye fragmenty / Vestnik Kazan.tehnol.un-ta. - 2012. - T15, №7. - S 29-30.
2. Yusupova L.M. Sredstva biologicheskoy zaschity mnogocelevogo naznacheniya na osnove hlorproizvodnyh nitrobenzofuroksana / Vestnik Kazan.tehnol.un-ta. - 2004. -№1. - S 103-111.
3. Granik V.G., Grigor'ev N.B. Oksid azota (NO). M.: «Vuzovskaya kniga», 2004, 359 s.
4. Feelisch M., Schönafinge, K., Noack E. // Biochem. Pharmacol., 1992, V. 44, P. 1149-1157.
5. Ghigo D., Heller R., Calvino R., Alessio P., Fruttero R., Gasco A., Bosia A., Pescarmona G. // Biochem. Pharmacol., 1992, V. 43(6), P. 1281-1288.
6. Bendale A.R., Shah R. Narkhede S.B., Jadhav A.G., Vidyasagar G. // Int. J. Pharm. Tech. Research, 2011, V. 3(2), P. 841-851.
7. Boga C., E. Vecchio Del, Forlani L., Goumnt R., Terrier F., Tozzi S. // Chem. Eur. J., 2007, V. 13(34), P. 9600-9607.