Description of a novel type of ionic nanogels with controlled spatial distribution of polymer chains, and discuss the potential application of these nanogels as carriers for delivery of anticancer drugs.Ionic nanogels appear to be promising and versatile macromolecular platform for carrier-based delivery of charged anticancer therapeutics or diagnostic molecules.Toxicity studies with drug-loaded nanogels indicate a better safety profile compared to free drug treatments.
Блок сополимеры, ионные наногели, доставка лекарств, фолатная направленная доставка, рак яичников, Block copolymer, ionic nanogels, drug delivery, folate -targeted delivery, ovarian cancer
1. Bronich, T.K., Keifer, P.A., Shlyakhtenko, L.S., Kabanov, A.V. Polymer micelle with cross-linked ionic core. J Am ChemSoc 127, 8236-8237 (2005).
2. Nukolova, N.V., Oberoi, H.S., Cohen, S.M., Kabanov, A.V., Bronich, T.K. Folate-decorated nanogels for targeted therapy of ovarian cancer. Biomaterials 32, 5417-26 (2011).
3. Bontha, S., Kabanov, A.V., Bronich, T.K. Polymer micelles with cross-linked ionic cores for delivery ofanticancer drugs. J Control Release 114, 163-74 (2006).
4. Kim, J.O., Nukolova, N.V., Oberoi, H.S., Kabanov, A.V., Bronich, T.K. Block ionomer complexmicelles with cross-linked cores for drug delivery. PolymSciSer A ChemPhys 51, 708-718 (2009).
5. Bronich, T.K., Bontha, S., Shlyakhtenko, L.S., Bromberg, L., Hatton, T.A., Kabanov, A.V. Template-assisted synthesis of nanogels from Pluronic-modified poly(acrylic acid). J Drug Target 14, 357-66 (2006).
6. Oberoi, H.S., Laquer, F.C., Marky, L.A., Kabanov, A.V., Bronich, T.K. Core cross-linked block ionomer micelles as pH-responsive carriers for cis-diamminedichloroplatinum(II). J Control Release 153, 64-72 (2011).
7. Kim, J.O., Kabanov, A.V. &Bronich, T.K. Polymer micelles with cross-linked polyanion core for delivery of a cationic drug doxorubicin. J Control Release 138, 197-204 (2009).
8. Sahay, G., Kim, J.O., Kabanov, A.V., Bronich, T.K. The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents. Biomaterials 31, 923-33 (2010).
9. Kim, J., Oberoi, H.S., Bronich, T.K. Cross-linked polymer micelles with biodegradable ionic cores for anti-cancer drug delivery. Polymer Preprs 50, 372-373 (2009).
10. Kim, J.O., Sahay, G., Kabanov, A.V., Bronich, T.K. Polymeric micelles with ionic cores containing biodegradable cross-links for delivery of chemotherapeutic agents. Biomacromolecules 11, 919-26 (2010).
11. M.A. Ibragimov, Vestnik Kazanskogo tehnologicheskogo universiteta, 9, 119 - 126 (2012).
12. A. G. Liakumovich, A. P. Rahmatullina, M. A. Ibragimov, N. V. Galkina, D. G. Miloslavskiy, Vestnik Kazanskogo tehnologicheskogo universiteta, 20, 148 - 154 (2012).
