RAZRABOTKA OPYTNO-PROMYSHLENNOY TEHNOLOGII POLUCHENIYA 2 - METIL-4,6-DIOKSIPIRIMIDINA I POISK AL'TERNATIVNYH PUTEY EGO SINTEZA
Abstract and keywords
Abstract (English):
The paper describes the development of the improved synthesis of 2-methyl-4,6-dioxypyrimidine using acetamidine hydrochloride and malonic ester in methanol medium in the presence of sodium methylate, as well as two new alternative processes of 2-methyl-4,6-dioxypyrimidine preparation from more available raw materials: malon dya-mide and ethyl acetate, malonic ester and acetamide.

Keywords:
2 - метил-4,6-диоксипиримидин, опытно - промышленная технология, синтез, 1,1-диамино-2,2-динитрометилена, 2-methyl-4,6-dioxypyrimidine, pilot production technology, synthesis, 1,1-diamino-2,2-dinitromethylene
References

1. A.A. Astrat'ev, D.V. Dashko, A.Yu.Mershin, A.I. Stepanov, N.A. Urazgil'deev Zhur. Org.himii, 37, 5, 766 (2001).

2. Trzcinski et.al. J. of hazardous materials, 157, 605-612. (2008).

3. Pat. SShA 5.397.781, MPK S 07D 239/50 (1995).

4. Levineston P.F and Ronzio A.R. J.Am.Chem.Soc., 62, 606-607 (1940).

5. Chylen Z, Cudzilo S., Bladen J., and Pietzyk. Optimization of 1,1-diamino-2,2-dinitroethylene synthesis. New Trends in Research of Energetic Materials. Pardubice, CzechRepublic, 2005, p.p 212-216.

6. Czeskis B.A., Labelled J. Compands and Radiopharmactutials, 47, 10, 699-704 (2004).

7. Allentoff A.J., Lago M.W., Ogan M., et.al. J. Labelled Compounds and Radiopharmactutials, 51, 1, 41-47 (2008).

8. Farard J., Loge C., Duflos M., et.al. Tefrahodron Leffers, 50, 41, 5729-5732 (2009).

9. Pat. RF 2461545, MPK S 07D 239/54 (2012).

10. Pat. RF 2503665, MPK S 07D 239/54 (2014).

11. Pat. RF 2503666 (2014).

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