DVUHSTADIYNYY SINTEZ 2-(P-(1-ADAMANTIL)METILFENILTIO)-4- (P(1-ADAMANTIL)METILFENILOKSI)-6-METILPIRIMIDINA

Titova E S; Rahimov A I; Babkin V A; Ignatov A V; Zaikov G E; Stoyanov O V; Pearce Eli M

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Home / Journals / Herald of Technological University / Volume 17 Issue 13 / DVUHSTADIYNYY SINTEZ 2-(P-(1-ADAMANTIL)METILFENILTIO)-4- (P(1-ADAMANTIL)METILFENILOKSI)-6-METILPIRIMIDINA

DVUHSTADIYNYY SINTEZ 2-(P-(1-ADAMANTIL)METILFENILTIO)-4- (P(1-ADAMANTIL)METILFENILOKSI)-6-METILPIRIMIDINA

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DVUHSTADIYNYY SINTEZ 2-(P-(1-ADAMANTIL)METILFENILTIO)-4- (P(1-ADAMANTIL)METILFENILOKSI)-6-METILPIRIMIDINA

Journal: HERALD OF TECHNOLOGICAL UNIVERSITY Volume 17 № 13 , 2025

Rubrics: STRUKTURA VESCHESTVA I TEORIYA HIMICHESKIH PROCESSOV

UDC 547.854.83:544.183.25

Titova E S ¹

Rahimov A I ²

Babkin V A ³

Ignatov A V ⁴

Zaikov G E ⁵

Stoyanov O V ⁶

Pearce Eli M ⁷

Author and publication information

Authors:

1. Volgogradskiy gosud. tehnich. un-t; Volgograd State Technical University

2. Volgogradskiy gosud. tehnich. un-t; RAEN; Russian Academy of Natural Sciences. Department “Organic Chemistry” of Volgograd State Technical University

3. RAE, Mezhdunarodnaya akademiya «Kontenant», Sebryakovskiy filial Volgogradskogo gosud. un-ta; international academy “Contenant”, Head of Science department of Volgograd State Architecture Building University, Sebryakov’s Branch

4. Sebryakovskiy filial Volgogradskogo gosud. un-ta; Volgograd State Architecture Building University, Sebryakov’s Branch

5. Mezhdunarodnaya akademiya nauk (Myunhen, Germaniya), Institut biohimicheskoy fiziki, RAN, Moskva; international academyof Science (Munich, Germany), Honored scientist of Russian Federation. Institute of Biochemical Physics, Moscow

6. KNITU; Kazan State Technical University

7. Institute Polytechnic University; Institute Polytechnic University

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Article

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Published

Received:

20.04.2023

Accepted:

01.08.2025

Published:

01.08.2025

Subject area:

UDC 547.854.83:544.183.25

Language:

Russian

Keywords:

2-(п-(1-адамантил)метилфенилтио)-4-(п(1-адамантил)метилфенилокси)-6-метилпиримидин, нуклеофильное замещение, 2-(para-(1-adamantyl)methyphenyllthio)-6-methylpyrimidin-4(3H)-one, nucleophylic substitution

Abstract and keywords

Abstract (English):
2-(para-(1-Adamantyl)methyphenyllthio)-4-(para(1-adamantyl)methyphenyloxi)-6-methylpyrimidin was synthesized by nucleophylic substitution reaction of bromine in para-(1-adamantyl)benzylbromid by S- and O-anions, generated from 6-methyl-2-thiouracil in two-stage.

Keywords:
2-(п-(1-адамантил)метилфенилтио)-4-(п(1-адамантил)метилфенилокси)-6-метилпиримидин, нуклеофильное замещение, 2-(para-(1-adamantyl)methyphenyllthio)-6-methylpyrimidin-4(3H)-one, nucleophylic substitution

References

1. S- i O-aniony, generiruemye iz 6-metil-2-tio-, 2-alkil(aralkil)tiouracilov, v sinteze S-monoi S-,O-dialkil-, benzilproizvodnyh: diss. … kand. him. nauk / Titova E.S. Volgograd, 2005.

2. Sposob polucheniya 1,3-di[4-(6-metil-4-pirimidinon-2-tio)metilfenil]adamantana. Rahimov A.I., Titova E.S. patent na izobretenie RUS 231141211.07.2006

3. Rahimov A.I., Popov Yu.V., Titova E.S Nukleofil'noe zameschenie v benzil 1-(hlormetil)-3-fenoksibenzilhloridah s uchastiem 4-metil-6-okso-1,6-digidro-2-pirimidintiolat aniona // Izvestiya volgogradskogo gosudarstvennogo tehnicheskogo universiteta. 2005. № 1. S. 61 - 64.

4. Rahimov A.I., Titova E.S. Osobennosti sinteza 2-alkil(arilalkil)tio-6-metilpirimidin-4(3N)-onov i 2-alkil(arilalkil)tio-4-alkil(arilalkil)oksi-6-metilpirimidinov // ZhOH. 2007. T. 43. № 1. S. 92-98.

5. Rahimov A.I., Titova E.S., Fedunov R.G., Babkin V.A., Stoyanov O. V., Zaikov G.E. Generaciya Si O-anionov iz 6-metil-2-tio-, 2-alkil(aralkil)tiouracilov v sinteze S-monoi S-,O-diproizvodnyh // Vestnik Kazanskogo tehnologicheskogo universiteta. - 2013. - T. 16, № 5. - C. 23-29.

6. Rahimov A.I., Titova E.S.Sintez simmetrichnyh i nesimmetrichnyh S-,O-diproizvodnyh 6-metil-2-tiouracila // Izvestiya volgogradskogo gosudarstvennogo tehnicheskogo universiteta. 2006. № 1. S. 66 - 72.

7. Rahimov A.I., Titova E.S., Fedunov R.G., Babkin V.A. Osobennosti nukleofil'nogo zamescheniya v alkil- i benzilgalogenidah anionami, generiruemymi iz 4-gidroksi-2-merkapto-6-metilpirimidina. Himiya geterociklicheskih soedineniy. 2008. № 6. S. 874-883.

8. Rahimov A.I., Titova E.S., Fedunov R.G., Babkin V.A., Belousova V. S., Rusanova S. N., Zaikov G.E. Reakcionnaya sposobnost' S- i O-anionov, generiruemyh iz 6-metil-2-tio-, 2-tioalkil(aralkil)uracilov // Vestnik Kazanskogo tehnologicheskogo universiteta. - 2013. - T. 16, № 5. - C. 16-20.

9. Rahimov A.I., Titova E.S., Fedunov R.G., Babkin V.A. Kvantovo-himicheskiy analiz reakcionnoy sposobnosti S- i O-anionov, generiruemyh iz 6-metil-2-tio-, 2-alkil(aralkil)tiouracilov. // Izvestiya volgogradskogo gosudarstvennogo tehnicheskogo universiteta. 2008.T. 1. № 5. S. 70 - 75.

10. Babkin V.A., Rahimov A.I., Titova E.S., Fedunov R.G., Reshetnikov R.A., Belousova V. S., Zaikov G.E. Kvantovo-himicheskie issledovaniya mehanizma sinteza 2-metil(benzil)tio-4-metil(benzil)oksipirimidina // Himicheskaya fizika i mezoskopiya. 2007. T. 9. № 3. S. 263-275.

11. Synthesis of 2-alkyl(aralkyl)sulfanyl-6-methylpyrimidin-4(3h)-ones and 4-alkyl(aralkyl)oxy-2-alkyl(aralkyl)sulfanyl-6-methylpyrimidines. Rakhimov A.I., Titova E.S. Russian Journal of Organic Chemistry. 2007. T. 43. № 1. S. 96-102.

12. Rahimov A.I., Babkin V.A., Titova E.S., Fedunov R.G., Belousova V.S., Zaikov G.E Teoreticheskiy analiz reakcionnoy sposobnosti s- i o-anionov, generiruemyh iz 6-metil-2-tio-, 2-tioalkil(aralkil) uracilov // V sbornike: Teoreticheskie i prikladnye aspekty kvantovo-himicheskih raschetov unikal'nyh molekulyarnyh sistem sbornik statey: k 59-letiyu so dnya rozhdeniya professora V. A. Babkina; pod redakciey V. A. Babkina. Volgograd, 2011. S. 41-50.

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