The ability of chitosan polymer enhance lysostaphin lysis of the cell walls of staphylococci was demonstrated. It has been found that the potentiation of lysostaphin activity depends on the molecular weight of chitosan and the pH of the reaction medium. In mildly acidic conditions chitosan had the greatest activating effect with an average molecular weight and in weakly alkaline conditions - low molecular weight sample had the greatest activating effect. The results of the lead to the assumption that one of the mechanisms of antibacterial action of chitosan, which is to enhance the degradation of the cell wall of the bacteria in the presence of their own autolysins by chitosan polymer.
хитозан, антибактериальная активность, молекулярная масса, лизостафин, chitosan, molecular weight, antibacterial activity, lysostaphin
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