Encapsulation of bioactive substance vitamin E (α-tocopherol acetate) in molecular organized structures - micelles of hydroxyethylated compounds: block-copolymer Pluronic P123 and decaethylene glycol monododecyl ether C 12EO 10 have been studied. The aggregation properties of surfactant and polymer in the presence of vitamin E have been investigated. Degree of solubilization and partition coefficient of α-tocopherol acetate between micelles and water have been measured by fluorescence spectroscopy. Partition coefficient of α-tocopherol acetate between micelles of C 12EO 10 and water is 359,7±0,007 and in micelles of Pluronic P123 is 182,8±0,032. It conforms to intensive partition of vitamin E in surfactant micelles due to the structure of micellar aggregates.
мицелла, неионный ПАВ, блок-сополимер, биологически активное вещество, витамин E, micelle, nonionic surfactant, block-copolymer, biologically active substance, vitamin E
1. Basak R., Bandyopadhyay R., Langmuir, 29, 4350−4356 (2013);
2. Shirin A., Cosgrove T., Castle Th.C., Grillo I., Prescott S.W., J. Phys. Chem. B, 116, 11545−11551 (2012);
3. Yuk S.H., Oh K.S., Cho S.H., Kim S.Y., Oh S., Lee J.H., Kim K., Kwon I.C., Mol. Pharmaceutics, 9, 230−236 (2012);
4. Chen Y.Yu., Wu H.C., Sun J.-S., Dong G.-C., Wang T.-W., Langmuir, 29, 3721−3729 (2013);
5. Torchilin, V.P., Advanced Drug Delivery Reviews, 54, 235-252 (2002);
6. Selivanova, N.M., Galeeva A.I., Gubaydullin A.T., Lobkov V.S., Galyametdinov Y.G, Journal of Physical Chemistry B, 116, 735-742 (2012);
7. Selivanova N.M.,Galeeva A.I., Sukhanov A.A., Gnezdilov O.I., Chachkov D.V., Galyametdinov Y.G., Journal of Physical Chemistry B, 117(17), 5355-5364 (2013);
8. Selivanova N.M., Kuzovkova M.A., Galyametdinov Yu.G., Vestnik Kazanskogo tehnologicheskogo universiteta, №(4), S. 85-88 (2013);
9. Selivanova N.M., Myasnikova Yu.S., Galyametdinov Yu.G., Vestnik Kazanskogo tehnologicheskogo universiteta, № 18. S. 129-133 (2013);
10. Selivanova N.M., Makarova D.V., Galyametdinov Yu.G., Izvestiya VUZov. Himiya i himicheskaya tehnologiya, T. 56, №. 10 S. 70-74 (2013);
11. Bugrin V. S., Kozlov M. Yu., Baskin I. I., Melik-Nubarov N.S., Vysokomolekulyarnye soedineniya, Seriya A, 49, № 4, S. 701-712 (2007);
12. Melik-Nubarov N.S., Kozlov M.Yu., Colloid. Polym. Sci. 276, 381-387 (1998).
